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KMID : 1100220040030020099
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Dementia and Neurocognitive Disorders
2004 Volume.3 No. 2 p.99 ~ p.104
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Association of Subcortical Ischemic Vascular Dementia with Homocysteine and MTHFR C677T Polymorphism
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Kim Hee-Jin
Kim Jee-Young
Kim Sook-Hui
Kim Won-Ki
Kim Yong-Sung
Choi Byung-Ok
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Abstract
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Background: Subcortical ischemic vascular dementia (SIVD) frequently causes dementia in elderly people, and elevated plasma homocysteine concentrations have been reported to be associated with vascular dementia. Although the homozygous C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene can induce hyperhomocysteinemia, the association between MTHFR C677T polymorphism and SIVD has not been studied. Therefore, we examined the association of SIVD with plasma homocysteine concentration and MTHFR C677T polymorphism.
Methods: We enrolled 58 patients with vascular dementia (VaD), 43 patients with SIVD, 69 lacunar infarct patients without vascualr dementia (LOD), and 232 healthy individuals and checked their fasting plasma homocysteine levels and analyzed the C677T polymorphism in the MTHFR gene.
Results: The mean plasma homocysteine level in VaD, SIVD, and LOD patients were significantly higher than that in healthy controls (p<0.01). The odds ratio adjusted with age, sex, hypertension, diabetes mellitus, and smoling were significantly higher in VaD (OR, 2.74; 95% CI, 1.04 to 7.23) and SIVD (OR, 3.12; 95% CI, 1.09 to 8.96) than that in controls. Compared with LOD, it was significantly higher in SIVD, but not in VaD (OR, 4.50; 95% CI, 1.05 to 19.26). In SIVD patients, the OR of plasma homocysteine level was higher in the TT genotype than those in the CC genotype (OR, 1.59; 95% CI, 1.01 to 2.49).
Conclusions: Our findings suggest that elevated plasma homocysteine concentration and the MTHFR 677TT genotype are associated with SIVD.
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KEYWORD
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Dementia, MTHFR, Gene, Homocysteine, Risk factor
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